Notice of 2018 Annual Meeting and Proxy Statement

Time and Date
9:00 a.m., Eastern Daylight Time (EDT), on Thursday, April 26, 2018

Place
Hilton Short Hills Hotel, 41 John F. Kennedy Parkway, Short Hills, New Jersey 07078, +1-973-379-0100

Record Date
You can vote your shares if you were a shareholder of record at the close of business on February 27, 2018.

Audio Webcast
Available at www.pfizer.com, starting at 9:00 a.m., EDT, on Thursday, April 26, 2018. A replay will be available through the first week of May 2018.

ITEMS OF BUSINESS

To elect 12 members of the Board of Directors, each until our next Annual Meeting and/or until his or her successor has been duly elected and qualified.
To ratify the selection of KPMG LLP as our independent registered public accounting firm for the 2018 fiscal year.
To conduct an advisory vote to approve our executive compensation.
To approve the Pfizer Inc. French Sub-Plan under the 2014 Stock Plan.
To consider three shareholder proposals, if properly presented at the Meeting.
To transact any other business that properly comes before the Meeting and any adjournment or postponement of the Meeting.

VOTING YOUR SHARES IS QUICK AND EASY—YOU CAN EVEN VOTE USING YOUR SMARTPHONE OR TABLET.

HOW TO VOTE	For registered holders and Pfizer Savings Plan participants: (Shares are registered in your name with Pfizer's transfer agent, Computershare, or held in the Pfizer Savings Plan)	For beneficial owners: (Shares are held in a stock brokerage account or by a bank or other holder of record)
Internet*	www.investorvote.com/pfe	www.proxyvote.com
Telephone*	Within the U.S., U.S. territories & Canada +1-800-652-VOTE (8683) – toll-free Outside of the U.S., U.S. territories & Canada +1-781-575-2300 – standard rates apply	+1-800-454-VOTE (8683) – toll-free
Mail	Complete, sign and return the proxy card	Complete, sign and return the voting instruction card
* You will need to provide your control number that appears on the right-hand side of the enclosed proxy card or voting instruction card.

HOW TO VOTE

For registered holders and Pfizer Savings Plan participants:
(Shares are registered in your name with Pfizer's transfer agent, Computershare, or held in the Pfizer Savings Plan)

Internet*
www.investorvote.com/PFE

Telephone*
Within the U.S., U.S. territories & Canada
+1-800-652-VOTE (8683) – toll-free

Outside of the U.S., U.S. territories & Canada
+1-781-575-2300 – standard rates apply

Mail
Complete, sign and return the proxy card

HOW TO VOTE

For beneficial owners:
(Shares are held in a stock brokerage account or by a bank or other holder of record)

Internet*
www.proxyvote.com

Telephone*
+1-800-454-VOTE (8683) – toll-free

Mail
Complete, sign and return the voting instruction card

* You will need to provide your control number that appears on the right-hand side of the enclosed proxy card or voting instruction card.

MATERIALS TO REVIEW

This booklet contains our Notice of 2018 Annual Meeting and Proxy Statement. Our 2017 Financial Report is included as Appendix A and is followed by certain Corporate and Shareholder Information. None of Appendix A, the Corporate and Shareholder Information, or the accompanying Letter to Shareholders from our Chairman and CEO, are a part of our proxy solicitation materials.

If you received a Notice of Internet Availability and would like a printed copy of the materials, please follow the instructions provided in your notice. Alternatively, follow the instructions included on how to vote online.

This Notice of 2018 Annual Meeting and Proxy Statement and a proxy or voting instruction card are being mailed or made available to shareholders starting on or about March 15, 2018.

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE ANNUAL MEETING OF SHAREHOLDERS TO BE HELD ON APRIL 26, 2018

This Notice of 2018 Annual Meeting and Proxy Statement and the 2017 Financial Report and Corporate and Shareholder Information are available on our website at https://investors.pfizer.com/financials/annual-reports/default.aspx. Except as stated otherwise, information on our website is not considered part of this Proxy Statement.

Margaret M. Madden signature
Margaret M. Madden
Senior Vice President and Corporate Secretary, Chief Governance Counsel
March 15, 2018

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